The relationship between intelligence and duration of circulatory arrest with deep hypothermia
| Autor: | J. M. Simpson, T. B. Cartmill, R. K. Oates, J. A. B. Turnbull |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Heart Defects
Congenital Male Pulmonary and Respiratory Medicine Resuscitation Time Factors Adolescent Intelligence Neuropsychological Tests Atrial septal defects law.invention Hypothermia Induced law Reaction Time Cardiopulmonary bypass Humans Medicine Child Tetralogy of Fallot Intelligence Tests Psychological Tests Cardiopulmonary Bypass Intelligence quotient business.industry Infant Hypothermia medicine.disease Great arteries Anesthesia Circulatory system Heart Arrest Induced Regression Analysis Female Surgery medicine.symptom business Cardiology and Cardiovascular Medicine |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 110(3):786-792 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(95)70112-5 |
| Popis: | A total of 114 children (51 with tetralogy of Fallot, 30 with transposition of the great arteries, and 33 with ventricular septal defect) who had these defects repaired with the use of deep hypothermia and circulatory arrest were assessed for intellectual and neuropsychologic function at an average of 9 to 10 years after the operation. Children with preoperative intellectual handicaps or postoperative neurologic complications were excluded. These children were compared with 54 who had atrial septal defects repaired with the use of cardiopulmonary bypass. The only significant difference in the neuropsychologic measures was that the bypass group had reaction times 2 to 3 seconds shorter on average than those of the hypothermic circulatory arrest group. Although there was no significant difference in intelligence quotient between the groups, a relationship between intelligence quotient and arrest time was found. Regression analysis of intelligence quotient against duration of arrest showed a significant decrease in intelligence quotient with increasing arrest time (slope = -0.36; p = 0.002; 95% confidence interval, -0.59, -0.14) indicating a decrease of 3 to 4 intelligence quotient points for each extra 10 minutes of arrest time. It appears that deep hypothermia with circulatory arrest for cardiac operations in children does not fully protect the brain, with a linear relationship existing between the amount of impairment and the duration of circulatory arrest. (J T HORAC C ARDIOVASC S URG 1995;110:786-92) |
| Databáze: | OpenAIRE |
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