Comparison of Invasive and Non-Invasive Tests Diagnosis and Monitoring of Helicobacter Pylori Infection in Children
| Autor: | H Sprecher, Orly Eshach-Adiv, B Hino, Raanan Shamir, D Berkowitz, Corina Hartman, Rami Eliakim, Arie Levine |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Abdominal pain Spirillaceae Urea breath test Rapid urease test Sensitivity and Specificity Gastroenterology Endoscopy Gastrointestinal Helicobacter Infections Diagnosis Differential Immunoenzyme Techniques Feces Predictive Value of Tests Internal medicine medicine Humans Prospective Studies Child Prospective cohort study Antigens Bacterial Helicobacter pylori biology medicine.diagnostic_test business.industry Reproducibility of Results bacterial infections and mycoses biology.organism_classification Urease Surgery Breath Tests Population Surveillance Predictive value of tests Pediatrics Perinatology and Child Health Female medicine.symptom Gastritis business |
| Zdroj: | Journal of Pediatric Gastroenterology and Nutrition. 39:519-523 |
| ISSN: | 0277-2116 |
| DOI: | 10.1097/00005176-200411000-00013 |
| Popis: | Background There are few reports which the tests used for diagnosing Helicobacter pylori infection and monitoring its eradication in children. Study aims Prospective evaluation of invasive (gastric histology, rapid urease test [RUT]) and non-invasive (stool antigen [FemtoLab H. pylori], urea breath test [UBT]) tests in the diagnosis of H. pylori infection and post-treatment eradication in children and adolescents. Methods Ninety-two patients (50 male, 42 female) referred for upper gastrointestinal endoscopy were prospectively enrolled. UBT was performed and stool specimens collected for monoclonal enzyme immunoassay for H. pylori antigen (FemtoLab) 1 to 4 days before endoscopy. H. pylori in gastric biopsies was evaluated by RUT and staining with hematoxylin-eosin and giemsa. Eradication therapy was given to children with abdominal pain and H. pylori gastritis. FemtoLab H. pylori and UBT were repeated 6 weeks after the end of triple therapy. Results Histology identified H. pylori in 49 of 92 (53%) subjects. Concordance between histology and RUT was found in 78 of 92 children. FemtoLab H. pylori was positive in 41 of 78 (52.6%) children with sensitivity, specificity, positive and negative predictive values of 97.5%, 94.7%, 95.1% and 97.3%, respectively. For UBT, these values were 100%, 96.9%, 97.5% and 100%, respectively. Twenty-six of 36 patients who received triple therapy returned for eradication evaluation. Tests for H. pylori antigen in stool were positive in 10 of 26 and for UBT in 11 of 26. Conclusion Stool antigen (FemtoLab) and UBT were equally effective in diagnosing and confirming eradication of H. pylori infection in children. |
| Databáze: | OpenAIRE |
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