Oral cyclosporin inhibits the expression of contact hypersensitivity in man
| Autor: | Peter S. Friedmann, Sam Shuster, Janet McLelland, John N. S. Matthews, E. M. Higgins |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Administration Oral Differential Threshold Cyclosporins Human skin Dermatology Dermatitis Contact medicine.disease_cause Biochemistry Allergen Cyclosporin a Humans Medicine European standard Antigens Molecular Biology Allergic contact dermatitis Skin Tests business.industry Contact hypersensitivity Patch test Middle Aged medicine.disease Immunology Female Chronic contact dermatitis business |
| Zdroj: | Journal of Dermatological Science. 2:79-83 |
| ISSN: | 0923-1811 |
| DOI: | 10.1016/0923-1811(91)90015-p |
| Popis: | The expression of delayed contact hypersensitivity was studied in 6 patients with chronic contact dermatitis treated with cyclosporin A (CsA) 5 mg/Kg/day. Quantitative patch test challenge was used to establish individual dose-response curves and threshold concentration to certain allergens in the European Standard Battery. In all 6 patients, responses were reduced over the whole range of allergen concentrations, and in the 5 in whom the threshold for expression of contact hypersensitivity could be determined, the threshold was raised by CsA therapy. In addition, the clinical manifestations of allergic contact dermatitis underwent complete resolution within 2–3 weeks of CsA therapy. It was concluded that CsA inhibits expression of delayed contact hypersensitivity reactions in human skin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|