Identification of two distinct bovine parainfluenza virus type 3 genotypes
| Autor: | Timothy J. Mahony, Paul F. Horwood, Jennifer L. Gravel |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Genotype
Sequence analysis Molecular Sequence Data Sequence Homology Genome Viral Biology Respirovirus Infections Genome DNA sequencing Viral Matrix Proteins chemistry.chemical_compound Phylogenetics Virology Animals Humans Parainfluenza Virus 3 Bovine Phylogeny Genetics Phylogenetic tree Nucleic acid sequence Sequence Analysis DNA chemistry RNA Viral Cattle DNA |
| Zdroj: | Journal of General Virology. 89:1643-1648 |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/vir.0.2008/000026-0 |
| Popis: | The partial gene sequencing of the matrix (M) protein from seven clinical isolates of bovine parainfluenza virus type 3 (BPIV-3), and the complete sequencing of a representative isolate (Q5592) was completed in this study. Nucleotide sequence analysis was initiated because of the failure of in-house BPIV-3 RT-PCR methods to yield expected products for four of the isolates. Phylogenetic reconstructions based on the nucleotide sequences for the M-protein and the entire genome, using all of the available BPIV-3 nucleotide sequences, demonstrated that there were two distinct BPIV-3 genotypes (BPIV-3a and BPIV-3b). These newly identified genotypes have implications for the development of BPIV-3 molecular detection methods and may also impact on BPIV-3 vaccine formulations. |
| Databáze: | OpenAIRE |
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