Approach for tuberculosis-associated immune reconstitution inflammatory syndrome in an HIV-negative patient
| Autor: | Félix Pierre Kuhn, Michèle Rebecca Weber, Jan Fehr, Marisa B. Kaelin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Tuberculosis medical management Human immunodeficiency virus (HIV) TB and other respiratory infections HIV Infections Case Report Disease medicine.disease_cause Sputum culture Mycobacterium tuberculosis Immune reconstitution inflammatory syndrome Immune Reconstitution Inflammatory Syndrome medicine Humans infections Abscess Tuberculosis Pulmonary medicine.diagnostic_test biology business.industry General Medicine medicine.disease biology.organism_classification migration and health Regimen Tuberculosis Spinal business |
| Zdroj: | BMJ Case Reports |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2019-232639 |
| Popis: | A male refugee from the Middle East was diagnosed with pulmonary tuberculosis and Pott’s disease with paravertebral abscess. After starting the standard regimen, the sputum culture converted to negative and the patient’s general condition improved. Six weeks later, the patient presented with clinical worsening of known symptoms, new appearance of focal neurological deficits and progress of radiological features showing progression of the paravertebral abscess. Immune reconstitution inflammatory syndrome with Mycobacterium tuberculosis (TB-IRIS) was presumed, and treatment with high-dose steroids was started. Due to recurrent relapses while tapering, corticosteroids had to be given over a prolonged period. After treatment completion, the patient was in a good general condition, abscesses had decreased and neurological deficits were in complete remission. This case presents the rare manifestation of TB-IRIS in HIV-negative patients and its management in a high-income country. |
| Databáze: | OpenAIRE |
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