An ERG Gene Analysis in Two Cases with Metastatic Castration-resistant Prostate Cancer in Which Abiraterone Demonstrated Long-term Efficacy

Autor: Junichi Mochida, Satoru Takahashi, Nozomu Kawata, Masahiro Ogawa, Tsuyoshi Yoshizawa, Kenya Yamaguchi, Hitomi Ryuzaki, Daisuke Obinata
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Oncology
Male
medicine.medical_specialty
Prednisolone
Case Report
030204 cardiovascular system & hematology
Castration resistant
03 medical and health sciences
Prostate cancer
chemistry.chemical_compound
0302 clinical medicine
Transcriptional Regulator ERG
Internal medicine
abiraterone
Antineoplastic Combined Chemotherapy Protocols
Internal Medicine
medicine
durable complete response
Humans
Neoplasm Metastasis
Gene
fluorescence in situ hybridization
Complete response
Aged
medicine.diagnostic_test
business.industry
General Medicine
Middle Aged
medicine.disease
Abiraterone
Prostatic Neoplasms
Castration-Resistant
Treatment Outcome
chemistry
metastatic castration-resistant prostate cancer
Fish
ERG gene
030211 gastroenterology & hepatology
Androstenes
business
Erg
Fluorescence in situ hybridization
Zdroj: Internal Medicine
ISSN: 1349-7235
0918-2918
Popis: We analyzed the ERG gene status using fluorescence in situ hybridization (FISH) in two chemotherapy-naive cases with metastatic castration-resistant prostate cancer (mCRPC) in which abiraterone demonstrated a long-term durable complete response. FISH identified Class 1 Edel and Class 2+ Edel in case 1, and Class 1 Edel in case 2. Our experience suggests that abiraterone may be effective in cases with mCRPC and ERG gene abnormalities, particularly Class 2+ Edel or Class 1 Edel. This is the first report of two cases with mCRPC that simultaneously investigated the ERG gene status and clinical aspects, including image evaluations and pathology.
Databáze: OpenAIRE
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