Secular trends of candidemia at a Brazilian tertiary care teaching hospital
| Autor: | Isabela C. Leme V. Cruz, Marcio Nucci, Isadora Ortiz, Gloria Barreiros, Paula Rocha Braga, Simone A. Nouér |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Antifungal Agents Adolescent Epidemiology 030106 microbiology lcsh:QR1-502 Tertiary care lcsh:Microbiology Teaching hospital lcsh:Infectious and parasitic diseases Tertiary Care Centers Young Adult 03 medical and health sciences Patient Admission Amphotericin B Internal medicine medicine Humans lcsh:RC109-216 Hospital Mortality Young adult Child Hospitals Teaching Fungemia Aged Candida Aged 80 and over business.industry Incidence Incidence (epidemiology) Candidemia Middle Aged medicine.disease Secular variation Infectious Diseases Female business Brazil medicine.drug |
| Zdroj: | Brazilian Journal of Infectious Diseases, Vol 22, Iss 4, Pp 273-277 (2018) Brazilian Journal of Infectious Diseases v.22 n.4 2018 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Volume: 22, Issue: 4, Pages: 273-277, Published: AUG 2018 Brazilian Journal of Infectious Diseases, Vol 22, Iss 4, Pp 273-277 |
| ISSN: | 1413-8670 |
| Popis: | Background: Candidemia is the most frequent invasive fungal disease in hospitalized patients, and is associated with high mortality rates. The main objective of this study was to evaluate changes in the epidemiology of candidemia at a tertiary care hospital in a 21-year period. Methods: We evaluated all episodes of candidemia diagnosed between 1996 and 2016 at a University-affiliated tertiary care hospital in Brazil. We arbitrarily divided the study period in 3: 1996–2002 (period 1), 2003–2009 (period 2) and 2010–2016 (period 3). Incidence rates were calculated using hospital admissions as denominator. Results: We observed 331 episodes of candidemia. The incidence was 1.30 episodes per 1000 admissions, with no significant change over time. Candida albicans (37.5%), C. tropicalis (28.1%), C. parapsilosis (18.4%) and C. glabrata (6.9%) were the most frequent species. The proportion of patients receiving treatment increased (65.5%, 79.4% and 74.7% in periods 1, 2 and 3, respectively, p = 0.04), and the median time from candidemia to treatment initiation decreased from 4 days in period 1 (range 0–32 days) to 2 days in period 2 (range 0–33 days) and 2 days in period 3 (range 0–14 days, p |
| Databáze: | OpenAIRE |
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