Myasthenia gravis and myasthenic syndrome: simulation of twitch strength with or without therapy
| Autor: | Shashi B. Bhatt, Anton Amann, Vladimir Nigrovic |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Physiology Neuromuscular transmission Neuromuscular Junction Stimulus (physiology) Cellular and Molecular Neuroscience Postsynaptic potential Physiology (medical) Internal medicine Myasthenia Gravis medicine Humans Computer Simulation Receptors Cholinergic Receptor Acetylcholine receptor business.industry medicine.disease Myasthenia gravis Acetylcholine Lambert-Eaton Myasthenic Syndrome Endocrinology Neurology (clinical) Cholinesterase Inhibitors business Lambert-Eaton myasthenic syndrome medicine.drug Muscle Contraction |
| Zdroj: | Musclenerve. 32(6) |
| ISSN: | 0148-639X |
| Popis: | To examine the quantitative relationship between indirectly evoked twitch and decreases in the number of either postsynaptic receptors or acetylcholine molecules released by a single stimulus, we studied these variables in a computer-simulated model of neuromuscular transmission. Twitch strength decreased if the number of receptors decreased to below 30% of normal or the number of acetylcholine molecules released by a stimulus decreased to below 80%. Inhibition of acetylcholine hydrolysis to 50% restored twitch strength in the presence of a decreased number of receptors. However, twitch strength was more easily restored to normalcy by augmenting the release of acetylcholine, if the release was diminished by disease. The simulations mimic the clinically known therapeutic outcomes in certain disorders of neuromuscular transmission. These results provide useful quantitative insights into the relationship between acetylcholine receptors or the stimulus-induced release of acetylcholine and muscle function in myasthenia gravis or Lambert-Eaton myasthenic syndrome. |
| Databáze: | OpenAIRE |
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