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Avramenko А. А., Smolyakov S. N. Peculiarities of pathogenesis of gastric cancer formed in the treatment of chronic non-atrophic gastritis by proton pump inhibitors. Journal of Education, Health and Sport. 2018;8(11):546-556. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2530853 http://ojs.ukw.edu.pl/index.php/johs/article/view/6440 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author(s) 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 19.11.2018. Revised: 22.11.2018. Accepted: 30.11.2018. UDC 616.33-002-006:542.978 PECULIARITIES OF PATHOGENESIS OF GASTRIC CANCER FORMED IN THE TREATMENT OF CHRONIC NON -ATROPHIC GASTRITIS BY PROTON PUMP INHIBITORS А. А. Avramenko*, S. N. Smolyakov** *Petro Mohyla Black Sea National University, Nikolaev **Regional Oncology Center, Nikolaev (Ukraine) aaahelic@gmail.com Abstract The data on the duration of use of proton pump inhibitors, the nature and duration of stress, and the timing of the first clinical and instrumentally confirmed manifestations of gastric cancer in 10 patients with chronic non-atrophic gastritis who were treated with proton pump inhibitors both in the form of monotherapy and the composition of standard regimens of H. pylori therapy. It was found that the duration of taking proton pump inhibitors ranged from 2 days to 2 months, and the duration of stress - from 2 years to 45 years. The first clinical manifestations occurred from the 1st to the 5th month after the end of the treatment, and the deterioration of the patients' condition proceeded quickly, “avalanche-like” within 7-10 days. Key words: chronic non-atrophic gastritis, proton pump inhibitors, gastric cancer. |
