Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status
| Autor: | K. P. Strohl, Song X. Dong, Jie S. Wang, Y. C. Wei, Pei An, L. H. Wang, Fang Han, Jing Li, E. Mignot, Hui Y. Gao, M. Z. He, Mei Li, Ling Lin, Zifen Gao |
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| Rok vydání: | 2010 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Adult Male Sleep Wake Disorders medicine.medical_specialty China Cataplexy Polysomnography Body Mass Index Hypercapnia Internal medicine HLA-DQ Antigens medicine HLA-DQ beta-Chains Humans Hypoxia Narcolepsy Hyperoxia Sleep disorder Orexins Membrane Glycoproteins medicine.diagnostic_test business.industry Respiration Neuropeptides Intracellular Signaling Peptides and Proteins medicine.disease Respiratory Function Tests Endocrinology Female medicine.symptom business Sleep Respiratory minute volume |
| Zdroj: | The European respiratory journal. 36(3) |
| ISSN: | 1399-3003 |
| Popis: | We hypothesised that hypocretin (orexin) plays a role in the determination of ventilatory chemosensitivity. 130 patients with narcolepsy-cataplexy (mean ± SD age 20 ± 10 yrs, 69% male) and 117 controls (22 ± 6.9 yrs, 62% male) were recruited and tested for human leukocyte antigen (HLA)-DQB1*0602 status, hyperoxia hypercapnic (change in minute ventilation (δV'(E))/carbon dioxide tension (δP(CO(2))) L·min(-1)·mmHg(-1)) and hypoxic (δV'(E) /change in arterial oxygen saturation measured by probe oximetry (δS(p,O(2))) L·min(-1) per %S(p,O(2))) responsiveness, and by spirometry. Hypocretin deficiency was determined either by measures of cerebrospinal fluid hypocretin-1 (37 patients) or by positive HLA-DQB1*0602 status. All patients and 49% of controls underwent polysomnography and multiple sleep latency testing. Despite similar spirometric values, patients had a higher apnoea/hypopnoea index (AHI) (2.8 ± 5.4 versus 0.8 ± 1.6 h(-1); p = 0.03) and lower minimal oxygen saturation during sleep (87% ± 7 versus 91 ± 4%; p = 0.0002), independent of age, sex and body mass index. Patients had depressed hypoxic responsiveness (0.13 ± 0.09 versus 0.19 ± 0.13 L·min(-1) per %S(p,O(2)); p0.0001), independent of AHI, but hypercapnic responsiveness did not differ. Examined by HLA status, positive (26 out of 117) controls had lower hypoxic but similar hypercapnic responsiveness than those marker-negative (0.13 ± 0.08 versus 0.20 ± 0.14 L·min(-1) per %S(p,O(2)); p0.0001). Thus, a lower hypoxic responsiveness in the narcolepsy-cataplexy group is a result of DQB1*0602 status rather than the clinical features of disease. |
| Databáze: | OpenAIRE |
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