Dynamics of Persistent TT Virus Infection, as Determined in Patients Treated with Alpha Interferon for Concomitant Hepatitis C Virus Infection
| Autor: | Fabrizio Maggi, Maria Linda Vatteroni, Elisabetta Andreoli, Patrizia Isola, Sabina Fagnani, Silvano Presciuttini, Santino Marchi, Mauro Pistello, Guido Antonelli, Claudia Fornai, Mauro Bendinelli |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Torque teno virus Hepatitis C virus Immunology Alpha interferon Viremia Hepacivirus Biology Virus Replication medicine.disease_cause Microbiology Virus Virology medicine Humans Interferon-alpha Hepatitis C Middle Aged Viral Load medicine.disease Viral replication Insect Science Chronic Disease Pathogenesis and Immunity Female Viral load |
| Zdroj: | Journal of Virology. 75:11999-12004 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.75.24.11999-12004.2001 |
| Popis: | TT virus (TTV) is a recently identified widespread DNA virus of humans that produces persistent viremia in the absence of overt clinical manifestations. In an attempt to shed light on the dynamics of chronic infection, we measured the levels of TTV in the plasma of 25 persistently infected patients during the first 3 months of alpha interferon (IFN-α) treatment for concomitant hepatitis C virus (HCV) infection. The first significant decline of TTV loads was observed at day 3 versus day 1 for HCV. Subsequently, the loads of TTV became progressively lower in most patients, but some initial responders relapsed before the end of the follow-up, suggesting that at least in some subjects the effects of IFN on TTV can be very short-lived. No correlation between the responses of TTV and HCV to therapy was found. Fitting the viremia data obtained during the first week of treatment into previously developed mathematical models showed that TTV sustains very active chronic infections, with over 90% of the virions in plasma cleared and replenished daily and a minimum of approximately 3.8 × 10 10 virions generated per day. Low levels of TTV were occasionally detected in the peripheral blood mononuclear cells of patients who had cleared plasma viremia, thus corroborating previous results showing that these cells may support TTV replication and/or persistence. |
| Databáze: | OpenAIRE |
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