Garcinol Reduces Obesity in High‐Fat‐Diet‐Fed Mice by Modulating Gut Microbiota Composition
| Autor: | Chia Yi Teng, Chi-Tang Ho, Min-Hsiung Pan, Nagabhushanam Kalyanam, Pei Sheng Lee |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adipocytes White Adipose tissue Inflammation Intra-Abdominal Fat Gut flora Diet High-Fat Mice 03 medical and health sciences chemistry.chemical_compound Internal medicine Adipocyte medicine Animals Obesity 030109 nutrition & dietetics biology Terpenes Adenylate Kinase food and beverages Akkermansia medicine.disease biology.organism_classification Lipids Gastrointestinal Microbiome Mice Inbred C57BL 030104 developmental biology Endocrinology chemistry Adipogenesis Dysbiosis Signal transduction medicine.symptom Endocannabinoids Food Science Biotechnology |
| Zdroj: | Molecular Nutrition & Food Research. 63:1800390 |
| ISSN: | 1613-4133 1613-4125 |
| DOI: | 10.1002/mnfr.201800390 |
| Popis: | Scope Obesity has become a major health problem worldwide and is associated with low-grade chronic inflammation and intestinal dysbiosis. This study is conducted to investigate the chemopreventive effects of garcinol, a polyisoprenylated benzophenone derivative isolated from the fruit rind of Garcinia indica. How garcinol protects against obesity in high-fat diet (HFD)-induced mice is delineated and whether its anti-obesity effects are related to gut microbiota has been determined. Methods and results The results show that garcinol reduces HFD-fed mice body weight gain and relative visceral adipose tissue fat weight in a dose-dependent manner. Furthermore, garcinol markedly reduces the plasma levels of glutamate pyruvate transaminase, total cholesterol, and triacylglycerol. The 16S rRNA gene sequence data indicate that garcinol not only reverses HFD-induced gut dysbiosis-as indicated by the decreased Firmicutes-to-Bacteroidetes ratios-but also controls inflammation by increasing the intestinal commensal bacteria, Akkermansia. In addition, the AMP-activated protein kinase α signaling pathway involved in adipocyte adipogenesis is also affected by garcinol. Conclusion Taken together, these results demonstrate for the first time that garcinol can prevent HFD-induced obesity and may be used as a novel gut microbiota modulator to prevent HFD-induced gut dysbiosis and obesity-related metabolic disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text