Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface
| Autor: | Guosong Wu, Ying Zhao, Xiaoli Zhao, Chong Wang, Eva Y. W. Chong, Paul K. Chu, Kenneth M.C. Cheung, Shuilin Wu, Haobo Pan, Hoi Man Wong, So Ching Lui, Kelvin W.K. Yeung |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Plasma Gases Polymers Bone-Implant Interface Nanotechnology 02 engineering and technology Surface finish 010402 general chemistry 01 natural sciences Osseointegration Cell Line Polyethylene Glycols Rats Sprague-Dawley Benzophenones Mice Implants Experimental Osteogenesis Materials Testing Surface roughness Peek Animals General Materials Science Ketones 021001 nanoscience & nanotechnology Plasma-immersion ion implantation Surface energy Rats 0104 chemical sciences Surface modification Female 0210 nano-technology Biomedical engineering |
| Zdroj: | ACS Applied Materials & Interfaces. 8:3901-3911 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of the biopolymer. |
| Databáze: | OpenAIRE |
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