Treatment of anaemia in inflammatory bowel disease with iron sucrose
| Autor: | BG Danielson, Stergios Kechagias, Göran Bodemar, Sven Almer |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Sucrose medicine.medical_specialty Adolescent Iron sucrose Ferric Compounds Inflammatory bowel disease Gastroenterology Glucaric Acid Crohn Disease Internal medicine medicine Humans Infusions Intravenous Aged Retrospective Studies Aged 80 and over Ferric Oxide Saccharated biology business.industry Anemia Iron deficiency Middle Aged medicine.disease Ulcerative colitis Ferritin Treatment Outcome Iron-deficiency anemia Erythropoietin Concomitant Retreatment Immunology Hematinics biology.protein Colitis Ulcerative Female business medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 39:454-458 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | Background: Inflammatory bowel disease (IBD)-associated anaemia usually responds to intravenous iron. If not, additive treatment with erythropoietin has been proposed. The objective of the present retrospective study was to evaluate the effectiveness of treatment with iron sucrose alone. Methods: Sixty-one patients with IBD and anaemia (average haemoglobin 97 g/L) were treated with iron sucrose (iron dose 1.4 ± 0.5 g). The indications for iron sucrose were poor response and/or intolerance to oral iron. Treatment response was defined as an increase in haemoglobin of ≥20 g/L or to normal haemoglobin levels (>120 g/L). Two independent investigators retrospectively assessed laboratory variables, clinical findings, and concomitant medication. Results: Two patients were transferred to other hospitals after treatment and therefore could not be evaluated. Fifty-four of the remaining 59 patients (91%) responded within 12 weeks. Sixty percent of the patients had responded within 8 weeks. Five patients had no or only a partial response to iron sucrose of which three had prolonged gastrointestinal blood losses. Eight patients with normal or elevated levels of ferritin could be considered to have anaemia of chronic disease, and all of them responded to iron sucrose. During a follow-up period of 117 ± 85 (4-291) (mean ± s (standard deviation) (range)) weeks 19 patients (32%) needed at least one second course of iron sucrose because of recurrent disease. Conclusions: Anaemia associated with IBD can be successfully treated with intravenously administered iron sucrose, provided that bowel inflammation is treated adequately and enough iron is given. Treatment with iron sucrose is safe. Follow-up of haemoglobin and iron parameters to avoid further iron deficiency anaemia is recommended. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|