Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency
| Autor: | Maria Blettner, Marisa Hübner, M Jung, Stephanie Korn, Roland Buhl |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Cross-sectional study Asthma severity BMI immune system diseases Forced Expiratory Volume Asthma control Prevalence Vitamin D and neurology Humans Corticosteroids Medicine Prospective Studies Vitamin D Prospective cohort study Lung function Aged Calcifediol Asthma business.industry Research Body Weight Sputum Middle Aged Vitamin D Deficiency Acquired immune system medicine.disease Interleukin-10 respiratory tract diseases Eosinophils Cross-Sectional Studies Immunology Female business |
| Zdroj: | Respiratory Research |
| ISSN: | 1465-9921 |
| Popis: | Background Vitamin D has effects on the innate and adaptive immune system. In asthmatic children low vitamin D levels are associated with poor asthma control, reduced lung function, increased medication intake, and exacerbations. Little is known about vitamin D in adult asthma patients or its association with asthma severity and control. Methods Clinical parameters of asthma control and 25-hydroxyvitamin D (25(OH)D) serum concentrations were evaluated in 280 adult asthma patients (mean ± SD: 45.0 ± 13.8 yrs., 40% male, FEV1 74.9 ± 23.4%, 55% severe, 51% uncontrolled). Results 25(OH)D concentrations in adult asthmatics were low (25.6 ±11.8 ng/ml) and vitamin D insufficiency or deficiency (vitamin D |
| Databáze: | OpenAIRE |
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