Effects of Selenium In Vitro on Human T-Lymphocyte Functions and K-562 Tumor Cell Growth
| Autor: | D Lucas, Ronald R. Watson, S Moriguchi, L Tobin, J. C. Mayberry, B McRae |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male Rosette Formation T-Lymphocytes Lymphocyte Immunology chemistry.chemical_element Lymphocyte Activation Cell Line Natural killer cell Selenium Structure-Activity Relationship chemistry.chemical_compound medicine Humans Immunology and Allergy biology Pokeweed mitogen Biological activity Cell Biology T lymphocyte Middle Aged Molecular biology Killer Cells Natural Sodium selenate Kinetics medicine.anatomical_structure chemistry Leukemia Myeloid Concanavalin A biology.protein Female Interferons Cell Division |
| Zdroj: | Journal of Leukocyte Biology. 39:447-456 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1002/jlb.39.4.447 |
| Popis: | In vitro E-rosette formation, lymphocyte mitogenesis, and natural killer (NK) cell activity of human blood lymphocytes were strongly inhibited by high concentrations (10−4 M) of sodium selenite, sodium selenate, and selenium dioxide. Lower concentrations (10−5 or 10−7 M) also inhibited E-rosette formation and natural killer cell activity against K-562 tumor cells. Lymphocyte transformation induced by concanavalin A (con A) or pokeweed mitogen (PWM) was also inhibited by all selenium compounds tested, but only at the highest concentrations (10−5 and 10−4 M). There was depression of the total number of viable lymphocytes following incubation with selenium dioxide only at a high concentration (10−4 M). Interferon production was enhanced at lower levels (10−9 to 10−6M) of selenium dioxide while a higher concentration (10−5 and 10−4M) appeared to inhibit its production. The mechanism of inhibition by selenium compounds (10−4 M) is due, in part, to the decrease of viable lymphocytes. It is unclear how other and lower concentrations (10−7 or 10−9 M) of selenium compounds inhibit E-rosette formation, NK activity, or K-562 tumor cell growth. |
| Databáze: | OpenAIRE |
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