Alternative approaches to treat bacterial infections: targeting quorum-sensing
| Autor: | Janice Chiou, Priyanka Chatterjee, Michael Otto, Pipat Piewngam |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Computer science 030106 microbiology Virulence Computational biology Gram-Positive Bacteria Microbiology 03 medical and health sciences 0302 clinical medicine Drug Development Drug Resistance Multiple Bacterial Virology Gram-Negative Bacteria Animals Humans 030212 general & internal medicine Gram-Positive Bacterial Infections Quorum Sensing Bactericidal effect Pathogenicity Anti-Bacterial Agents Quorum sensing Infectious Diseases Quorum Quenching Gram-Negative Bacterial Infections |
| Zdroj: | Expert Review of Anti-infective Therapy. 18:499-510 |
| ISSN: | 1744-8336 1478-7210 |
| DOI: | 10.1080/14787210.2020.1750951 |
| Popis: | Introduction: The emergence of multi- and pan-drug-resistant bacteria represents a global crisis that calls for the development of alternative anti-infective strategies. These comprise anti-virulence approaches, which target pathogenicity without exerting a bacteriostatic or bactericidal effect and are claimed to reduce the development of resistance. Because in many pathogens, quorum-sensing (QS) systems control the expression of virulence factors, interference with QS, or quorum-quenching, is often proposed as a strategy with a broad anti-virulence effect.Areas covered: We discuss the role and regulatory targets of QS control in selected Gram-positive and Gram-negative bacteria, focusing on those with clinical importance and QS control of virulence. We present the components of QS systems that form possible targets for the development of anti-virulence drugs and discuss recent research on quorum-quenching approaches to control bacterial infection.Expert opinion: While there has been extensive research on QS systems and quorum-quenching approaches, there is a paucity of in-vivo research using adequate animal models to substantiate applicability. In-vivo research on QS blockers needs to be intensified and optimized to use clinically relevant setups, in order to underscore that such drugs can be used effectively to overcome problems associated with the treatment of severe infections by antibiotic-resistant pathogens. |
| Databáze: | OpenAIRE |
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