Microbiota modulation and effects on metabolic biomarkers by orange juice: a controlled clinical trial
| Autor: | Dragan Milenkovic, Melaine Priscila Fidelix, Katia Sivieri, Thais Borges Cesar |
|---|---|
| Přispěvatelé: | Laboratory of Nutrition, School of Pharmaceutical Science, São Paulo State University, Department of Internal Medicine, Universität Zürich [Zürich] = University of Zurich (UZH), University of California [Davis] (UC Davis), University of California, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Brazilian Association of Citrus Exporters - CitrusBR 754/50/01/2015Coordination for the Improvement of Higher Education Personnel, Brazil (CAPES) 001, University of California (UC), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Universität Zürich [Zürich] (UZH), Universidade Estadual Paulista (Unesp), UNH CRNH Auvergne |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose 030309 nutrition & dietetics medicine.medical_treatment Urine digestive system 03 medical and health sciences chemistry.chemical_compound Feces Young Adult Insulin resistance fluids and secretions Lactobacillus medicine Humans Food science Naringin Triglycerides 030304 developmental biology Orange juice 0303 health sciences biology Insulin Prebiotic Body Weight General Medicine medicine.disease biology.organism_classification 3. Good health Gastrointestinal Microbiome Fruit and Vegetable Juices stomatognathic diseases chemistry Female Insulin Resistance [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Citrus × sinensis Biomarkers Food Science Citrus sinensis |
| Zdroj: | Food and Function Food and Function, Cambridge : Royal Society of Chemistry, 2020, 11 (2), pp.1599-1610. ⟨10.1039/C9FO02623A⟩ Food and Function, 2020, 11 (2), pp.1599-1610. ⟨10.1039/C9FO02623A⟩ Food and Function, Cambridge : Royal Society of Chemistry, 2020, ⟨10.1039/C9FO02623A⟩ Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 2042-6496 |
| DOI: | 10.1039/C9FO02623A⟩ |
| Popis: | Made available in DSpace on 2020-12-12T01:16:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01 The impact of habitual orange juice consumption on microbiota, lipid and sugar metabolism was investigated in a controlled clinical trial. The clinical procedure is as follows: ten women who had a regular diet without orange juice for 30 days (OJ-free diet), followed by a regular diet plus 300 ml d-1 orange juice for 60 days (OJ-Diet), and 30 days with a regular diet without orange juice (Washout). Biochemical and dietary parameters were monitored, and blood, urine and stool samples were collected every 30 days until the end of the study. Hesperidin and naringin metabolites in the urine were identified by UHPLC, and the microbiota composition of the feces was determined by 16S rRNA. At the end of the OJ-Diet, there was a reduction in glucose (-6.5%), insulin (-33%), insulin resistance (-44%), LDL-C (-16%) and triglycerides (-30%). After the washout, these parameters returned to their initial values. There were no changes in the body weight or fat during the experimental time. The intestinal bacteria, Lactobacillus spp., Akkermansia spp., and Ruminococcus spp., increased after the intervention with orange juice. In addition, an inverse correlation was detected between these bacteria and glycemia, insulin, HOMA-IR, triglycerides, total cholesterol and LDL-C, but a direct correlation with HDL-C. In conclusion, orange juice showed a prebiotic effect, modulating the intestinal microbiota while improving the glycemia and lipid profiles. Laboratory of Nutrition School of Pharmaceutical Science São Paulo State University-UNESP Department of Internal Medicine UC Davis School of Medicine University of California Université Clermont Auvergne INRA UNH CRNH Auvergne Laboratory of Nutrition School of Pharmaceutical Science São Paulo State University-UNESP |
| Databáze: | OpenAIRE |
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