Time-dependent improvement of liver inflammation, fibrosis and metabolic liver function after successful direct-acting antiviral therapy of chronic hepatitis C
| Autor: | Thomas Damgaard Sandahl, Tea Lund Laursen, Lena Hagelskjaer Kristensen, Konstantin Kazankov, Cecilie Brøckner Siggaard, Britta Tarp, Henning Grønbæk, Holger Jon Møller, Peter Derek Christian Leutscher, Alex Lund Laursen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
Male Time Factors Cirrhosis Sustained Virologic Response Sofosbuvir Gastroenterology Liver disease 0302 clinical medicine Liver Function Tests Fibrosis INFECTION Medicine Prospective Studies 030212 general & internal medicine CIRRHOSIS TRANSIENT ELASTOGRAPHY portal hypertension Middle Aged Treatment Outcome Infectious Diseases Liver SUSTAINED VIROLOGICAL RESPONSE Elasticity Imaging Techniques Portal hypertension VIRUS Female 030211 gastroenterology & hepatology medicine.symptom NONINVASIVE ASSESSMENT medicine.drug medicine.medical_specialty Inflammation metabolic liver function Antiviral Agents 03 medical and health sciences Virology Internal medicine MACROPHAGE ACTIVATION MARKER Humans chronic hepatitis C Hepatology business.industry fibrosis NATURAL-HISTORY Hepatitis C Chronic medicine.disease GALACTOSE ELIMINATION CAPACITY direct-acting antiviral therapy Liver function business Transient elastography FOLLOW-UP |
| Zdroj: | Laursen, T L, Siggaard, C B, Kazankov, K, Sandahl, T D, Møller, H J, Tarp, B, Kristensen, L H, Laursen, A L, Leutscher, P & Grønbæk, H 2020, ' Time-dependent improvement of liver inflammation, fibrosis and metabolic liver function after successful direct-acting antiviral therapy of chronic hepatitis C ', Journal of Viral Hepatitis, vol. 27, no. 1, pp. 28-35 . https://doi.org/10.1111/jvh.13204 Laursen, T L, Siggaard, C B, Kazankov, K, Sandahl, T D, Møller, H J, Tarp, B, Kristensen, L H, Laursen, A L, Leutscher, P & Grønbaek, H 2020, ' Time-dependent improvement of liver inflammation, fibrosis and metabolic liver function after successful direct-acting antiviral therapy of chronic hepatitis C ', Journal of Viral Hepatitis, vol. 27, no. 1, pp. 28-35 . https://doi.org/10.1111/jvh.13204 |
| Popis: | Sofosbuvir-based direct-acting antiviral (DAA) therapy generally cures chronic hepatitis C (CHC) infections, and however, the effects on the underlying liver disease and the potential rate of recovery are unclear. We aimed to investigate the effects of DAA therapy on liver inflammation, fibrosis, metabolic function and cognitive function and the time course in CHC patients with advanced liver disease. Seventy-one CHC patients with advanced liver disease were studied before, during and one year after successful sofosbuvir-based DAA therapy. Liver inflammation was assessed by plasma sCD163 and sMR levels (ELISA), fibrosis by liver stiffness (transient elastography), function by galactose elimination capacity (GEC) and cognitive performance by continuous reaction time (CRT). During DAA therapy, we observed a rapid sCD163 decline from baseline to end of treatment (6.9 vs 3.8 mg/L, P |
| Databáze: | OpenAIRE |
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