Chlophentermine-induced abnormalcytoplasmic inclusions in peripheral blood cells of rats and guinea pigs
| Autor: | Renate Lüllmann-Rauch |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Pharmacology
Phospholipidosis Inclusion Bodies Pathology medicine.medical_specialty Phentermine Chlorphentermine Blood Cells Side effect Cytoplasmic inclusion Guinea Pigs Biology Toxicology Inclusion bodies Peripheral blood Rats Microscopy Electron Oral administration medicine Ultrastructure Animals medicine.drug |
| Zdroj: | Toxicology and applied pharmacology. 32(1) |
| ISSN: | 0041-008X |
| Popis: | Oral administration of chlorphentermine to rats and guinea pigs caused the formation of abnormal lamellated cytoplasmic inclusions in peripheral blood cells (lymphocytes, neutrophils, monocytes, plasma cells). Short-term experiments in rats revealed the lymphocytes to be most susceptible, containing abnormal inclusions after a single dose of chlorphentermine. The present ultrastructural findings correspond to those previously obtained in various other tissues of animals treated with chlorphentermine or with a variety of other drugs of amphiphilic character, and they are interpreted according to the previously proposed concept of drug-induced phospholipidosis. On the basis of the present results, lymphocytes of peripheral blood are proposed to be useful material for the examination of a particular side effect common to various amphiphilic compounds, i.e., drug-induced generalized phospholipidosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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