Metabolism of Reserpine-C14. II. Species Differences as Studied in vitro
| Autor: | Herbert Sheppard, Wen Hui Tsien |
|---|---|
| Rok vydání: | 1955 |
| Předmět: |
medicine.medical_specialty
Reserpine Metabolism In Vitro Techniques Biology Secologanin Tryptamine Alkaloids General Biochemistry Genetics and Molecular Biology Excretion Guinea pig Endocrinology Liver Species Specificity Biochemistry In vivo Internal medicine medicine Microsome Liberation Antihypertensive Agents medicine.drug Demethylation |
| Zdroj: | Experimental Biology and Medicine. 90:437-440 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-90-22058 |
| Popis: | Summary1. Liver slices of rat, mouse, dog, guinea pig, rabbit and pigeon were incubated with reserpine-C14. 2. Demethylation of the 4-methoxy position of trimethoxyben-zoic acid moiety of reserpine was observed to occur, with rat liver slices most active in this respect. 3. Hydrolysis of reserpine was observed to occur with liberation of free tri-methoxybenzoic acid. Guinea pig liver slices were most active in this respect. 4. Esteratic activity resides chiefly in the microsomes of guinea pig liver. 5. Demethylation or hydrolysis or both by liver slices is not correlated with dose requirement for typical tranquilizing response. 6. Rate of excretion of C14 by the guinea pig was studied in vivo after intravenous injection of reserpine-C14. |
| Databáze: | OpenAIRE |
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