Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors
| Autor: | Chi Ho Yu, Jong Hyuk Kim, W. G. Nho, Young S. Lyoo, Du Na Hwang, Jung-Hyang Sur, Ji Young Yhee, Keum Soon Im |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
endocrine system Pathology medicine.medical_specialty endocrine system diseases CD30 Vimentin urologic and male genital diseases Dogs Biomarkers Tumor medicine Animals Dog Diseases Tumor marker General Veterinary biology seminoma Seminoma medicine.disease Immunohistochemistry Sertoli cell tumor Placental alkaline phosphatase tumor markers Tumor progression dog Sertoli Cell Tumor biology.protein Original Article |
| Zdroj: | Journal of Veterinary Science |
| ISSN: | 1229-845X |
| DOI: | 10.4142/jvs.2009.10.1.1 |
| Popis: | Primary testicular tumors are the most common causes of cancer in male dogs. Overall, the majority of canine patients should be cured by testicular surgery. However, tumor markers are not well-known in veterinary medicine. We sought to determine using immunohistochemistry whether the combined human testicular tumor markers (placental alkaline phosphatase, OCT3/4, CD30, alpha-fetoprotein, inhibin-alpha, vimentin, c-KIT, and desmin) are expressed in canine seminomas and Sertoli cell tumors (SCTs). We examined 35 canine testicular tumors, 20 seminomas and 15 SCTs. c-KIT was expressed markedly in canine seminomas. Both inhibin-alpha and vimentin were expressed significantly in canine SCTs. The results of this study demonstrate differences and similarities between tumor marker expression of testicular tumors in dogs and humans. All the main markers in current routine use are discussed as well as potential useful markers for benign and malignant tumors, and tumor progression. |
| Databáze: | OpenAIRE |
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