Sarcoidosis and lymphoma: a comparative study
| Autor: | Pascal Sève, Christiane Broussolle, Laura Weiler, Michel Pavic, Emmanuel Bachy, Pierre Faurie, Pauline Occelli, Hervé Ghesquières, Émilie Chalayer |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Lymphoma Sarcoidosis Chronic lymphocytic leukemia Follicular lymphoma Multimodal Imaging Gastroenterology Disease-Free Survival Young Adult immune system diseases hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Age of Onset Child Prolymphocytic leukemia Anaplastic large-cell lymphoma Aged Retrospective Studies business.industry Infant General Medicine Middle Aged medicine.disease Treatment Outcome Child Preschool Positron-Emission Tomography Concomitant Female Steroids Tomography X-Ray Computed business Diffuse large B-cell lymphoma |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1460-2393 1460-2725 |
| DOI: | 10.1093/qjmed/hcv039 |
| Popis: | Aim: To assess the clinical features and outcome of lymphoma when associated with sarcoidosis and to determine whether this association gives lymphoma a better prognosis. Design : Multicentre retrospective cohort study. Methods : Retrospective chart review. Results: Twenty-one patients were included (9 males, 12 females). Median age at sarcoidosis diagnosis was 48 years (range: 24–68 years). In 14 cases, lymphoma occurred within a previously known sarcoidosis. Five patients received a concomitant diagnosis of sarcoidosis and lymphoma, whereas lymphoma preceded sarcoidosis in two patients. Three patients were diagnosed with Hodgkin’s lymphoma and 18 patients with non-Hodgkin’s lymphoma (diffuse large B-cell lymphoma (DLBCL) ( n = 11), follicular lymphoma ( n = 2), chronic lymphocytic leukemia/small lymphocytic lymphoma ( n = 2), anaplastic large cell lymphoma ALK + ( n = 1), angioimmunoblastic T-cell lymphoma ( n = 1) and T-cell prolymphocytic leukemia ( n = 1)). Thirteen patients were alive and in complete remission. Median age at the time of diagnosis of sarcoidosis was lower in patients with concomitant lymphoma compared with patients with sarcoidosis preceding lymphoma (34 years vs. 51 years, P = 0.01). Patients presenting with DLBCL associated with sarcoidosis were compared with DLBCL without sarcoidosis. No statistical difference was found in the risk of death or progression between the two groups ( P = 0.685). Conclusions: We report here the largest series of lymphoma associated sarcoidosis patients. As opposed to previous studies, we observed a predominance of patients with DLBCL. Our study confirms the concept of the sarcoidosis-lymphoma syndrome. Large B-cell lymphoma does not have a better prognosis when associated with sarcoidosis. |
| Databáze: | OpenAIRE |
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