Polymorphism in ARE-I region of prostate-specific antigen gene associated with low serum testosterone level and high-grade prostate cancer
| Autor: | Martin Preyer, Petra Grösser, Michael Marberger, Mesut Remzi, Andrea Gsur, Georg Schatzl, Michael Micksche, Thomas Zidek, Julia Unterlechner, Gerald Haidinger |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype medicine.drug_class Urology urologic and male genital diseases Gastroenterology Prostate cancer Prostate Internal medicine medicine Humans Testosterone Promoter Regions Genetic Aged Polymorphism Genetic business.industry Prostatic Neoplasms Odds ratio Luteinizing Hormone Middle Aged Prostate-Specific Antigen medicine.disease Androgen Confidence interval Prostate-specific antigen medicine.anatomical_structure Endocrinology Receptors Androgen Follicle Stimulating Hormone business Hormone |
| Zdroj: | Urology. 65:1141-1145 |
| ISSN: | 0090-4295 |
| Popis: | Objectives To examine the impact of polymorphism in the androgen-responsive element I region of the prostate-specific antigen (PSA) gene on the serum testosterone level and Gleason score in patients with newly diagnosed, untreated prostate cancer (PCa). High-grade PCa is associated with a low serum testosterone level, and the testosterone level has been negatively correlated with the expression of PSA. Methods Endocrine factors (including testosterone, follicle-stimulating hormone, and luteotropic hormone), PSA level, prostate volume, and Gleason score were measured in 134 patients with untreated, biopsy-verified PCa. PSA polymorphism was determined by polymerase chain reaction-based methods using DNA from peripheral blood samples. Results Patients with the PSA G/G genotype had lower serum testosterone levels (3.5 ± 1.2 ng/mL) than those with the A/A genotype (4.3 ± 1.6 ng/mL) or the A/G genotype (4.4 ± 1.5 ng/mL). The PSA level in the A/A and A/G genotype groups were significantly lower than that in the G/G genotype group (18.2 ± 55.0 ng/mL versus 20.5 ± 27.6 ng/mL, P = 0.013). In a multiple logistic regression model, the odds ratio for the G/G polymorphism was significantly increased for Gleason score (odds ratio 2.4, 95% confidence interval 1.6 to 10.4; P = 0.02) and serum testosterone level (odds ratio 0.44, 95% confidence interval 0.36 to 0.94; P = 0.01) relative to genotypes A/A and A/G. Conclusions Our results showed that the PSA G/G genotype is associated with a greater Gleason score and serum PSA level but lower serum testosterone level and could be considered a risk factor for a poor outcome of PCa. |
| Databáze: | OpenAIRE |
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