Controlled drug release from biodegradable thermoresponsive physical hydrogel nanofibers
| Autor: | Susan Liao, Xian Jun Loh, Jun Li, Priscilla Peh, Colin Sng |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cell Survival
Polymers Polyesters Polyurethanes Nanofibers Pharmaceutical Science macromolecular substances Cell morphology Polyvinyl alcohol Hydrogel Polyethylene Glycol Dimethacrylate Polyethylene Glycols chemistry.chemical_compound Tissue engineering Polymer chemistry PEG ratio Cell Adhesion Animals Humans Cells Cultured Chemistry Temperature technology industry and agriculture Serum Albumin Bovine Fibroblasts Controlled release Electrospinning Chemical engineering Propylene Glycols Delayed-Action Preparations Nanofiber Cattle Ethylene glycol |
| Zdroj: | Journal of Controlled Release. 143:175-182 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2009.12.030 |
| Popis: | Hydrogel nanofiber mats based on thermoresponsive multiblock poly(ester urethane)s comprising poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG), and poly(e-caprolactone) (PCL) segments were fabricated by electrospinning. The hydrogel nanofiber mats were more water absorbent under cold conditions and shrunk when exposed to higher temperatures. The rate of protein release could be controlled by changing the temperature of the nanofiber environment. Cell culture studies on the nanofiber mats were carried out using human dermal fibroblasts, and healthy cell morphology was observed. The adherent viable cells were quantified by MTS after rinsing in excess buffer solution. The results showed that these nanofiber scaffolds supported excellent cell adhesion, comparable with the pure PCL nanofibers. The increased hydrophilicity of these hydrogel nanofiber mats led to a more rapid hydrolytic degradation, compared with the pure PCL nanofiber mats. These hydrogel nanofiber scaffolds could potentially be used as thermoresponsive biodegradable supporting structures for skin tissue engineering applications. |
| Databáze: | OpenAIRE |
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