Cutting Edge: Dominance by an MHC-Independent Inhibitory Receptor Compromises NK Killing of Complex Targets
| Autor: | Joseph A. Wahle, Kim H. T. Paraiso, William G. Kerr, Charles L. Sentman, Emily L. Goll, Amy L. Costello |
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| Rok vydání: | 2006 |
| Předmět: |
Cytotoxicity
Immunologic Immunology Cell Down-Regulation Biology Ligands Lymphocyte Activation Inhibitory postsynaptic potential Major histocompatibility complex Mice Antigens CD Signaling Lymphocytic Activation Molecule Family MHC class I medicine Animals Antigens Ly Immunology and Allergy Lectins C-Type Receptors Immunologic Receptor Cells Cultured Dominance (genetics) Mice Knockout Membrane Glycoproteins Histocompatibility Antigens Class I Inositol Polyphosphate 5-Phosphatases Cell Differentiation Cytotoxicity Tests Immunologic Phosphoric Monoester Hydrolases Up-Regulation Cell biology Killer Cells Natural Mice Inbred C57BL Cytolysis NK-receptor medicine.anatomical_structure biology.protein Receptors Natural Killer Cell Receptors NK Cell Lectin-Like Signal Transduction |
| Zdroj: | The Journal of Immunology. 176:7165-7169 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.176.12.7165 |
| Popis: | Inhibitory receptors that recognize MHC class I molecules regulate NK cell responses and self-tolerance. Recent evidence indicates that self-ligands not present in the MHC locus also can modulate NK function. In this study, we show that an inhibitory receptor that recognizes an MHC-independent ligand is over expressed in SHIP−/− mice at all stages of NK development and differentiation. Overexpression of this receptor compromises key cytolytic NK functions, including killing of allogeneic, tumor, and viral targets. These results further demonstrate the critical role that SHIP plays in regulation of the NK receptor repertoire and show that regulation of MHC-independent inhibitory receptors is crucial for NK recognition and cytolysis of complex targets. |
| Databáze: | OpenAIRE |
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