Evaluation Of Topical Anti-Inflammatory Steroid Formulations In An Arthus Model Of Inflammation
| Autor: | Marvin B. Goldlust, Douglas M. Palmer, Matthew A. Augustine |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Injections
Intradermal Screening test Administration Topical medicine.medical_treatment Anti-Inflammatory Agents Halcinonide Inflammation Dermatology Pharmacology Triamcinolone Acetonide Biochemistry Steroid Ointments Pregnenediones Edema Arthus Reaction Animals Medicine Glucocorticoids Molecular Biology Steroids Chlorinated business.industry Cream base Cell Biology Clinical trial Pregnadienetriols Rabbits medicine.symptom Topical anti-inflammatory business medicine.drug |
| Zdroj: | Journal of Investigative Dermatology. 66:157-160 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12481898 |
| Popis: | Formulations of a number of steroids were evaluated after topical application in a reversed passive Arthus test (RPA) in rabbits. Four 21-chlorosteroids in the same cream base were investigated. The preparations of SQ 18,566 (halcinonide) and SQ 20,811 showed anti-edema activity, but those of SQ 15,361 and SQ 20,589 were less active. Ointment formulations of halcinonide also reduced edema in the RPA. These results, coupled with previously reported clinical data, suggest that the RPA might be utilized to distinguish good from poor formulations of anti-inflammatory steroids prior to screening tests or clinical trials in humans. |
| Databáze: | OpenAIRE |
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