The effects of 3-hydroxybutyrate and glucose on human T cell responses toCandida albicans
| Autor: | R. Gregory, R.B. Tattersall, I. Todd, J. McElveen |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty T-Lymphocytes T cell Immunology Antigen-Presenting Cells Hydroxybutyrates Biology Lymphocyte Activation Microbiology Immune system Antigen Diabetes mellitus Internal medicine Candida albicans medicine Humans Immunology and Allergy 3-Hydroxybutyric Acid General Medicine T lymphocyte medicine.disease biology.organism_classification Ketoacidosis Glucose Infectious Diseases Endocrinology medicine.anatomical_structure Female Ketosis |
| Zdroj: | FEMS Immunology & Medical Microbiology. 7:315-320 |
| ISSN: | 1574-695X 0928-8244 |
| DOI: | 10.1111/j.1574-695x.1993.tb00413.x |
| Popis: | Diabetic patients are particularly susceptible to mucocutaneous candidosis. T lymphocytes are central to the induction of antigen-specific immune responses and may be sensitive to the biochemical abnormalities associated with poorly controlled diabetes; namely, hyperglycaemia and/or ketonemia. To examine this we have studied the effect of varying concentrations of glucose and 3-hydroxybutyrate (3-HB) in cultures of human T cells stimulated with Candida albicans antigen. Proliferation of T cells from six type 1 diabetic and six non-diabetic control subjects was significantly inhibited (both P |
| Databáze: | OpenAIRE |
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