Males and females differ in response to opioid agonist medications

Autor:	Hendrée E. Jones, Heather Fitzgerald, Rolley E. Johnson
Rok vydání:	2005
Předmět:	Drug Adult Male Narcotics media_common.quotation_subject Methadyl Acetate Medicine (miscellaneous) Treatment retention law.invention Sex Factors Randomized controlled trial Double-Blind Method Opioid Agonist law Medicine Humans media_common business.industry Opioid use Middle Aged Opioid-Related Disorders Buprenorphine Clinical trial Psychiatry and Mental health Clinical Psychology Treatment Outcome Anesthesia Female business Methadone medicine.drug
Zdroj:	The American journal on addictions. 14(3)
ISSN:	1055-0496
Popis:	Few clinical trials include sex as a factor. This analysis explored within-sex differences in response to opioid agonist medications. Males and females randomly assigned to buprenorphine, LAAM, or methadone were compared on opioid use and retention in treatment. Females receiving buprenorphine had less objective drug use than females receiving methadone, while males receiving LAAM had less objective drug use than males receiving buprenorphine. Retention in treatment was longer for both sexes receiving methadone versus LAAM. Within-subject change results indicate that all three medications benefit both sexes. Clinical trials should be designed to examine the impact of sex on outcomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515b12238f530ee9631660355f1e10ec https://pubmed.ncbi.nlm.nih.gov/16019973 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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