Diagnostic yield of capillary compared to venous glucose in the diagnosis of hypoglycorrhachia in children: A prospective, observational study
| Autor: | Juan David Farfán-Albarracín, Ingrid Lemus Espitia, María Camila Rueda Rodríguez, Sofy Helena Pérez, Hugo Andrés Téllez Prada, Oscar Mauricio Espitia Segura, Cristina Lorena Ramírez-Sierra, Ana Maritza Bedoya |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Adolescent CSF glucose Intraclass correlation Sensitivity and Specificity Gastroenterology Specimen Handling Veins 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Developmental Neuroscience Internal medicine medicine Humans Prospective Studies Child business.industry Infant General Medicine Gold standard (test) Capillaries Cross-Sectional Studies Glucose Child Preschool Pediatrics Perinatology and Child Health Hypoglycorrhachia Etiology Female Observational study Neurology (clinical) business 030217 neurology & neurosurgery Pediatric population |
| Zdroj: | Brain and Development. 43:63-68 |
| ISSN: | 0387-7604 |
| DOI: | 10.1016/j.braindev.2020.07.013 |
| Popis: | Introduction The ratio of cerebrospinal fluid (CSF) glucose and blood glucose is of major relevance, conducting to the diagnosis of hypoglycorrhachia, which is a sign of neuroinfection, as well as a number of neurological diseases of genetic or neoplastic etiology. Glucose in capillary sample (glucometry) is a low cost, readily available technique, as compared to venous glucose. This study aims to compare glucometry to venous glucose in the diagnosis of hypoglycorrhachia in pediatric population. Methods Prospective cross-sectional study based on data obtained from lumbar punctures in the period from February 2017 to January 2019 in a specialized pediatric institution in Colombia. Results 97 patients were analyzed, aged 1 month to 17 years old, mean 7.67 years, 52 (53.61%) were female. 26 (26.8%) were diagnosed with hypoglycorrhachia. Pearson correlation coefficient for absolute venous and capillary glucose was 0.54, and 0.55 for the ratios of CSF glucose/venous glucose and CSF glucose/glucometry, which support a linear correlation between the variables in both, absolute values and ratios. Intraclass correlation coefficient was calculated for both, the venous glucose and glucometry ratios, which was 0.52, revealing a moderate agreement among the tests. Sensitivity and specificity of CSF glucose/glucometry, as compared to gold standard are 73.1% and 60.6% respectively; whereas predictive positive value (PPV) and negative predictive value (NPV), were 40.4% and 86.0%. Conclusion Glucometry cannot replace the glucose in venous sample in the diagnosis of hypoglycorrhachia in children. |
| Databáze: | OpenAIRE |
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