Production of interleukin-10 in human fracture soft-tissue hematomas
| Autor: | James L. Hughes, Carl J. Hauser, Paul Scott, Philip J. Kregor, Meenakshi Devidas, Kenneth J. Hardy, Pratibha Joshi, Xinchun Zhou |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Critical Care and Intensive Care Medicine Fractures Bone Immunity Reference Values Transforming Growth Factor beta Internal medicine medicine Humans Pelvic Bones Volunteer Aged Retrospective Studies Aged 80 and over Hematoma business.industry Soft tissue Interleukin Immune modulation Middle Aged Internal Fixators Interleukin-10 Tibial Fractures Interleukin 10 Cytokine Endocrinology Emergency Medicine Female Interleukin-4 business Femoral Fractures Biomarkers Transforming growth factor |
| Zdroj: | Shock (Augusta, Ga.). 6(1) |
| ISSN: | 1073-2322 |
| Popis: | Clinical trauma suppresses immunity and experimental wound fluids have been shown to be immunosuppressive. To ascertain whether human wounds contain immunosuppressive cytokines, we assayed serum from fracture/soft-tissue hematomas (FSTH) of 22 patients for interleukin (IL)-10, transforming growth factor (TGF)-beta 1, and IL-4. Results were correlated to concurrent plasma cytokine concentrations in the same patients and in volunteer plasma. IL-10 was present in high concentration (1376 +/- 539 pg/mL) in all (7/7) FSTH24 h old. In FSTH24 h old, IL-10 was found intermittently and at lower levels (239 +/- 106 pg/mL, p = .011 vs. FSTH24 h old). IL-10 was rarely detectable in fracture patient plasma and never detectable (20 pg/mL) in normal plasma. No significant variations of IL-4 or total TGF-beta 1 were found in FSTH or plasma. FSTH are significant potential sources of IL-10 activity in trauma patients, which may be overlooked when only plasma is assayed. The potential for a relationship between cytokines found locally at sites of injury and clinical immune modulation in trauma requires further study. |
| Databáze: | OpenAIRE |
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