PET-measurable innate immune cell activation reduction in chronic active lesions in PPMS brain after rituximab treatment: a case report

Autor: Jussi, Lehto, Marcus, Sucksdorff, Marjo, Nylund, Roope, Raitanen, Markus, Matilainen, Laura, Airas
Rok vydání: 2022
Předmět:
Zdroj: Journal of Neurology. 270:2329-2332
ISSN: 1432-1459
0340-5354
Popis: To evaluate the effects of rituximab treatment on innate immune cell activation in primary progressive multiple sclerosis (PPMS).A 48-year-old woman with PPMS was started on rituximab shortly after diagnosis. [The PPMS patient had higher PK11195 DVRs and higher proportions of active voxels in the thalamus and the normal appearing white matter compared to the healthy control group. The thalamic and perilesional white matter DVRs and the proportions of active voxels decreased after rituximab treatment. The patient remained clinically stable during the 5-years follow-up.This case suggests that while a degree of smoldering activity persists, high efficacy B-cell-targeting therapy may contribute to reduced innate immune cell activation in PPMS brain areas relevant for disease progression. This case supports the therapeutic concept that controlling smoldering brain inflammation is beneficial for slowing down progression independent of relapses.
Databáze: OpenAIRE
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