Does the platelet function analyser (PFA-100) predict blood loss after cardiopulmonary bypass?
| Autor: | M. Fattorutto, Brigitte Ickx, Luc Barvais, Denis Schmartz, Olivier Pradier |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Excessive Bleeding
medicine.medical_specialty Platelet Function Tests Point-of-Care Systems Postoperative Hemorrhage Sensitivity and Specificity law.invention law Predictive Value of Tests Occlusion Cardiopulmonary bypass medicine Coagulopathy Humans Platelet Cardiopulmonary Bypass business.industry Platelet Count PFA-100 medicine.disease Cardiac surgery Anesthesiology and Pain Medicine Epinephrine Anesthesia Blood Platelet Disorders business medicine.drug |
| Zdroj: | British journal of anaesthesia. 90(5) |
| ISSN: | 0007-0912 |
| Popis: | This study was designed to determine if a new point-of-care test (PFA-100) platelet function analyser) that assesses platelet function predicts blood loss after cardiac surgery.and results. Blood samples from 70 patients were drawn before and after cardiopulmonary bypass (CPB) for PFA-100 measurements. The system consists of a cartridge in which a membrane and an aperture are coated with either collagen/adenosine-5'-diphosphate or collagen/epinephrine. The instrument determines the time required for full occlusion of the aperture (closure time). We observed a weak correlation between pre-CPB collagen/epinephrine closure time and second-hour mediastinal blood loss (r=0.34, P=0.01). The sensitivity and positive predictive value of the PFA-100 measurements were comparable to platelet count for predicting excessive bleeding after CPB (75 and 27% vs 100 and 25%, respectively).The PFA-100 is a logical test for detecting patients who could have excessive bleeding after CPB. However, the PFA-100 was not able to separate patients at low risk of subsequent bleeding from those who had substantial bleeding. |
| Databáze: | OpenAIRE |
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