Enhanced Glycation of Hemoglobin and Plasma Proteins Is Associated with Increased Lipid Peroxide Levels in Non-Diabetic Hypertensive Subjects
| Autor: | V. Sathiyapriya, Purushothaman Pavithran, N. Selvaraj, Hanumanthappa Nandeesha, Zachariah Bobby, Aparna Agrawal |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Blood Glucose Lipid Peroxides medicine.medical_specialty Glycosylation Thiobarbituric Acid Reactive Substances Lipid peroxidation Pathogenesis Hemoglobins chemistry.chemical_compound Glycation Malondialdehyde Internal medicine medicine Humans Glycated Hemoglobin business.industry Blood Proteins General Medicine Middle Aged Blood proteins Fructosamine Endocrinology chemistry Case-Control Studies Hypertension Lipid Peroxidation Hemoglobin Glycated hemoglobin business |
| Zdroj: | Archives of Medical Research. 38:822-826 |
| ISSN: | 0188-4409 |
| DOI: | 10.1016/j.arcmed.2007.05.008 |
| Popis: | Background Accumulating evidences indicate that lipid peroxidation and protein glycation play a vital role in the pathogenesis of cardiovascular disease. The purpose of the present study was to evaluate the levels of lipid peroxides and glycated proteins in non-diabetic hypertensive patients and to assess the possible nexus between them, among these subjects. Methods Thirty hypertensive patients and 25 normotensive subjects were enrolled in the present study. Lipid peroxides, glycated hemoglobin, and fructosamine levels were estimated in both groups. Results Lipid peroxides, glycated hemoglobin, and fructosamine levels were significantly increased in hypertensive subjects in comparison with normotensive subjects. When partial correlation analysis was performed, malondialdehyde was significantly associated with glycated hemoglobin and fructosamine. Conclusions An increased glycation of proteins was found in non-diabetic hypertensive subjects. These data also support the premise that lipid peroxidation per se plays a role in glycation of hemoglobin and plasma proteins. |
| Databáze: | OpenAIRE |
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