Are insulin-resistance and oxidative stress cause or consequence of aging
| Autor: | Dorota Stołtny, Małgorzata Muc-Wierzgoń, Sylwia Dzięgielewska-Gęsiak, Alicja Brożek, Ewa Wysocka |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male Aging medicine.medical_specialty 030209 endocrinology & metabolism 030204 cardiovascular system & hematology medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants General Biochemistry Genetics and Molecular Biology Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine medicine Humans Insulin Aged Original Research Glutathione Peroxidase biology Superoxide Dismutase Chemistry Atherosclerosis medicine.disease Lipids Oxidative Stress Endocrinology biology.protein Female Insulin Resistance Biomarkers Oxidative stress |
| Zdroj: | Exp Biol Med (Maywood) |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | Insulin resistance (IR) may be associated with oxidative stress and leads to cardiovascular disorders. Current research focuses on interplay between insulin-resistance indices and oxidant-antioxidant markers in elderly individuals with or without insulin-resistance. The assessment involved anthropometric data (weight, height, BMI, percentage of body fat (FAT)) and biochemical tests (glucose, lipids, serum insulin and plasma oxidant-antioxidant markers: Thiobarbituric Acid-Reacting Substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1) and total antioxidant status). Insulin resistance index (IR) assuming a cut-off point of 0.3 allows to divides groups into: insulin sensitive group (InsS) IR Impact statement Insulin resistance is associated with oxidative stress leading to cardiovascular diseases. However, little research has been performed examining elderly individuals with or without insulin-resistance. We demonstrate that antioxidant defense systems alone is not able to abrogate insulin action in elderly individuals at high risk for atherosclerosis, whereas the combined oxidant-antioxidant markers (thiobarbituric acid-reacting substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1), and total antioxidant status (TAS)) might be more efficient and perhaps produce better clinical outcome. In fact, a decrease in oxidative stress and strong interaction between antioxidant defense can be seen only among insulin-resistant elderly individuals. This is, in our opinion, valuable information for clinicians, since insulin-resistance is considered strong cardiovascular risk factor. |
| Databáze: | OpenAIRE |
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