Development of nodular regenerative hyperplasia (NRH) with portal hypertension following the administration of oxaliplatin for the recurrence of colon cancer
| Autor: | Masahisa Toyohara, Masao Fujimoto, Shinya Takeyama, Hideto Kawaratani, Junichi Yamao, Hiroshi Fukui, Chie Morioka, Hitoshi Yoshiji, Hiroaki Takaya, Keisuke Nakanishi, Masayoshi Sawai |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Organoplatinum Compounds Colorectal cancer medicine.medical_treatment Antineoplastic Agents Esophageal and Gastric Varices Gastroenterology Esophageal varices Internal medicine Hypertension Portal Internal Medicine Sclerotherapy Medicine Humans Chemotherapy Hyperplasia medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Oxaliplatin Treatment Outcome Liver Liver biopsy Colonic Neoplasms Portal hypertension Female Neoplasm Recurrence Local business Nodular regenerative hyperplasia medicine.drug |
| Zdroj: | Internal medicine (Tokyo, Japan). 54(4) |
| ISSN: | 1349-7235 |
| Popis: | Nodular regenerative hyperplasia (NRH) is associated with autoimmune and hematologic diseases and may lead to portal hypertension. We herein report a case of NRH diagnosed based on a liver biopsy. A 63-year-old woman developed esophageal varices and splenomegaly. She had undergone surgery for transverse colon cancer 24 years earlier and received systemic chemotherapy (FOLFOX4 including oxaliplatin) to treat lymph node metastasis 21 years after the operation. The present liver biopsy confirmed NRH, and, after two years, she received endoscopic injection sclerotherapy. Oxaliplatin was suspected to be the causative agent of NRH in this case. Therefore, physicians must consider the possibility of NRH in patients who receive chemotherapy. |
| Databáze: | OpenAIRE |
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