Effect of prior exposure to a lithium- and an amphetamine-paired flavor on the acoustic startle response in rats
| Autor: | Linda A. Parker, Shadna A. Rana |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Taste Startle response Reflex Startle genetic structures medicine.drug_class Experimental and Cognitive Psychology Pharmacology Developmental psychology Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Lithium Carbonate Moro reflex medicine Antiemetic Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Amphetamine Ecology Evolution Behavior and Systematics Flavor medicine.diagnostic_test 05 social sciences food and beverages Classical conditioning equipment and supplies Startle reaction Rats Central Nervous System Stimulants Psychology Noise 030217 neurology & neurosurgery medicine.drug Antipsychotic Agents |
| Zdroj: | Journal of experimental psychology. Animal behavior processes. 33(2) |
| ISSN: | 0097-7403 |
| Popis: | The experiments reported here evaluated the hypothesis that an amphetamine-paired flavor elicits conditioned fear-arousal, whereas a lithium-paired flavor elicits conditioned nausea-disgust by examining the effect of prior flavor exposure on an acoustic startle reaction (ASR). Exposure to a lithium-paired flavor by intraoral infusion, either immediately prior to a startle session (Experiment 1) or during a startle session (Experiments 2 and 3), resulted in a blunted ASR. In contrast, intraoral infusion of an amphetamine-paired flavor resulted in a potentiated ASR. The blunted ASR produced by exposure to a lithium-paired flavor dramatically reversed to a potentiated ASR when rats were pretreated with the antiemetic drug ondansetron prior to the saccharin-lithium pairing (Experiment 3). The findings shed light on a mechanism by which rewarding drugs produce conditioned taste avoidance in rats. |
| Databáze: | OpenAIRE |
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