Effects of 1alpha-hydroxyvitamin D3 on serum calcium and immunoreactive parathyroid hormone in patients with chronic renal insufficiency
| Autor: | J. Kuska, Franciszek Kokot, Pietrek J |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Adolescent Urology medicine.medical_treatment Parathyroid hormone chemistry.chemical_element Calcium Phosphates Renal Dialysis Internal medicine medicine Chronic renal insufficiency Humans In patient Antigens Dialysis business.industry Hydroxycholecalciferols medicine.disease Alkaline Phosphatase Endocrinology chemistry Parathyroid Hormone Alkaline phosphatase Kidney Failure Chronic Secondary hyperparathyroidism Female Hyperparathyroidism Secondary business |
| Zdroj: | International urology and nephrology. 10(2) |
| ISSN: | 0301-1623 |
| Popis: | Six patients with chronic renal failure on regular dialysis treatment were given low doses (0.5--1.0 microgram/day) of 1alpha-hydroxyvitamin D3, monitoring the serum calcium, inorganic phosphate, immunoreactive parathyroid hormone concentration (IPTH) and alkaline phosphatase activity. The serum calcium rose in all patients after 7 days' treatment, in some subjects to hypercalcemic range; this effect persisted 6--14 days after withdrawal of 1alpha-hydroxyvitamin D3. The elevated serum IPTH rose in the first days of treatment, but later decreased to normal values. It is suggested that active vitamin D metabolites are necessary for normal response of parathyroid glands to variation in serum calcium. Low-dose 1alpha-hydroxyvitamin D3 treatment appears to be a promising method of correcting hypocalcemia and secondary hyperparathyroidism in chronic renal failure. Careful control of serum calcium is necessary, as hypercalcemia may occur even after minute doses of 1alpha-hydroxyvitamin D3. |
| Databáze: | OpenAIRE |
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