Changes in plasma amino acids after electroconvulsive therapy of depressed patients
| Autor: | Pirjo Saransaari, Jaana Suhonen, Esa Leinonen, Simo S. Oja, Martti Huuhka, Jukka Peltola, Tapani Keränen, Johanna Palmio |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Time Factors medicine.medical_treatment Glutamic Acid Pharmacology behavioral disciplines and activities chemistry.chemical_compound Electroconvulsive therapy mental disorders Humans Medicine Electroconvulsive Therapy Neurotransmitter gamma-Aminobutyric Acid Biological Psychiatry Aged chemistry.chemical_classification Aspartic Acid Depressive Disorder Major Electromyography business.industry Tryptophan Glutamate receptor Electroencephalography Middle Aged medicine.disease Amino acid Psychiatry and Mental health chemistry Mood disorders Mechanism of action Anesthesia Major depressive disorder Female medicine.symptom business |
| Zdroj: | Psychiatry Research. 137:183-190 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2005.07.010 |
| Popis: | There are indications that mood disorders may be related to perturbations in the amino acid transmitters. The amino acids may thus be targets of treatment of depression. The purpose of this pilot study was to measure the acute effects of a single administration of electroconvulsive therapy (ECT) on the plasma levels of amino acids in depressed patients. ECT was administered to 10 patients with major depressive disorder. Altogether 23 plasma amino acids were analyzed before and at 2, 6, 24 and 48 h after ECT. The levels of glutamate and aspartate increased at 6 h after ECT compared with the baseline. Also the levels of total tryptophan increased 2-24 h after ECT. There were also elevations in other amino acids at 6 and 24 h. The levels of gamma-aminobutyric acid (GABA) decreased at 2 h. In this study the acute effects of single ECT were associated with changes in the levels of glutamate, aspartate, GABA, tryptophan and some other amino acids. The preliminary data suggest that the therapeutic effects of ECT in depression may be due to mechanisms involving these amino acid transmitters. |
| Databáze: | OpenAIRE |
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