Recent Advances in Herbal Nanomedicines for Cancer Treatment
| Autor: | Amita Sahu, Dipak Kumar Sahu, Deepak Pradhan, Prativa Biswasroy, Goutam Rath, Goutam Ghosh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Curcumin Pharmacology 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Therapeutic index Neoplasms Nanotechnology Medicine business.industry General Medicine medicine.disease Cancer treatment Nanomedicine 030104 developmental biology Paclitaxel chemistry Drug development Drug delivery Nanoparticles Nanocarriers business 030217 neurology & neurosurgery Adverse drug reaction Camptothecin medicine.drug |
| Zdroj: | Current Molecular Pharmacology. 14:292-305 |
| ISSN: | 1874-4672 |
| DOI: | 10.2174/1874467213666200525010624 |
| Popis: | Cancer continues to be one of the deadliest diseases that adversely impacts the large population of the world. A stack of scientific documents reflects a huge number of potent plant-based anticancer drugs such as curcumin (CUR), podophyllotoxin, camptothecin (CPT), vincristine, vinblastine, paclitaxel (PTX), etc. that have been integrated into the modern practice of cancer treatment. The demand for natural products raises exponentially as they are generally considered to be safe, and devoid of critical toxic effects at the therapeutic dose when compared to their synthetic counterparts. Despite rising interest towards the potent phytoconstituents, formulation developer faces various challenges in drug development processes such as poor water solubility, low bioavailability, marginal permeability, and nonspecific drug delivery at the target site, etc. Further, adverse drug reaction and multidrug resistance are other critical issues that need to be addressed. Nanomedicines owing to their unique structural and functional attributes help to fix the above challenges for improved translational outcomes. This review summarises the prospects and challenges of a nanotechnology-based drug delivery approach for the delivery of plant-based anticancer drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|