Propensity-Score Matched Comparative Study on Effects of Intravenous Human Serum Albumin Administration in Critically Ill Adult Patients Receiving Parenteral Nutrition

Autor: Javier Mateu-de Antonio, X Fernández-Sala, Jaime Barceló-Vidal, Daniel Echeverría-Esnal
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
Parenteral Nutrition
Critical Care
030309 nutrition & dietetics
Bilirubin
Critical Illness
Medicine (miscellaneous)
Nutritional Status
Serum Albumin
Human
Gastroenterology
Severity of Illness Index
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Humans
Prospective Studies
Infusions
Intravenous
Propensity Score
Aged
Retrospective Studies
Aged
80 and over
0303 health sciences
Nutrition and Dietetics
biology
business.industry
Retrospective cohort study
Blood Proteins
Length of Stay
Middle Aged
Human serum albumin
Blood proteins
body regions
Transthyretin
Parenteral nutrition
Treatment Outcome
chemistry
Propensity score matching
Cohort
biology.protein
030211 gastroenterology & hepatology
Female
business
Biomarkers
medicine.drug
Zdroj: JPEN. Journal of parenteral and enteral nutrition. 43(3)
ISSN: 1941-2444
Popis: BACKGROUND The objective of this study was to assess the effect of intravenous human serum albumin administration (IV HSA) on nutrition markers, including non-serum-albumin plasma protein levels, in adult critically ill patients receiving parenteral nutrition (PN). METHODS This was a retrospective study of prospectively collected data. Patients included in an initial cohort were patients who initiated IV HSA within 24 hours of start of PN. A second cohort who did not received IV HSA during PN was manually selected, matching several variables. Subsequently, both cohorts were propensity-score matched, resulting in 2 final cohorts: the cohort receiving IV HSA (ALB) and the cohort not receiving IV HSA (NOALB). RESULTS A total of 42 patients, 21 in each cohort, entered the study. Both cohorts were similar in demographics, anthropometrics, comorbidities, diagnoses, PN composition, and severity of the disease, biochemistry, and nutrition markers. Patients in the ALB cohort received IV HSA at a dose of 30.0 g/day during 5 days. The ALB cohort presented higher values of final serum albumin level and serum albumin level change from baseline, but also presented lower values of final non-serum-albumin plasma protein levels and their change and lower final prealbumin. In addition, bilirubin in the ALB cohort increased, whereas it decreased in the NOALB cohort. CONCLUSION Patients receiving IV HSA and PN for several days increased serum albumin level, but decreased non-serum-albumin plasma protein levels. In addition, bilirubin clearance could be slightly impaired in these patients.
Databáze: OpenAIRE
Externí odkaz: