Large-scale, high-resolution data acquisition system for extracellular recording of electrophysiological activity
| Autor: | Milena Koudelka-Hep, Alessandro Maccione, S. Neukom, Y. Bornat, Luca Berdondini, Sergio Martinoia, Pierre-André Farine, K. Imfeld |
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| Rok vydání: | 2008 |
| Předmět: |
Computer science
Biomedical Engineering Video Recording Action Potentials Image processing Integrated amplifier Membrane Potentials Data acquisition Electronic engineering Animals Computer vision Myocytes Cardiac Image resolution Cells Cultured CMOS sensor business.industry Signal Processing Computer-Assisted Video processing Multielectrode array Frame rate Rats Electrophysiology Temporal resolution Artificial intelligence business Microelectrodes |
| Zdroj: | IEEE transactions on bio-medical engineering. 55(8) |
| ISSN: | 1558-2531 |
| Popis: | A platform for high spatial and temporal resolution electrophysiological recordings of in vitro electrogenic cell cultures handling 4096 electrodes at a full frame rate of 8 kHz is presented and validated by means of cardiomyocyte cultures. Based on an active pixel sensor device implementing an array of metallic electrodes, the system provides acquisitions at spatial resolutions of 42 microm on an active area of 2.67 mm x 2.67 mm, and in the zooming mode, temporal resolutions down to 8 micros on 64 randomly selected electrodes. The low-noise performances of the integrated amplifier (11 microV (rms)) combined with a hardware implementation inspired by image/video processing concepts enable high-resolution acquisitions with real-time preprocessing capabilities adapted to the handling of the large amount of acquired data. |
| Databáze: | OpenAIRE |
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