Increased release of atrial natriuretic polypeptides in rats with DOCA-salt hypertension
| Autor: | Tokuichiro Sugimoto, Atsuro Miyata, Yasunobu Hirata, Kenji Kangawa, Tsuneaki Sugimoto, Tsukasa Toshimori, Hisayuki Matsuo, Hiroshi Masuda, Hiroaki Matsuoka, Masao Ishii |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Sodium chemistry.chemical_element Blood Pressure Peptide hormone Sodium Chloride Doca salt General Biochemistry Genetics and Molecular Biology Internal medicine Extracellular fluid medicine Silicon rubber Animals cardiovascular diseases General Pharmacology Toxicology and Pharmaceutics Desoxycorticosterone Saline ATRIAL NATRIURETIC POLYPEPTIDES business.industry Myocardium Rats Inbred Strains General Medicine Rats Endocrinology Blood pressure chemistry Hypertension business hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor |
| Zdroj: | Life sciences. 38(15) |
| ISSN: | 0024-3205 |
| Popis: | This study compared atrial and plasma concentrations of immunoreactive alpha-rat atrial natriuretic polypeptide (i alpha-rANP) in rats given tap water (control), a 1% saline solution (salt), deoxycorticosterone acetate (DOCA) and DOCA plus 1% saline solution (DOCA-salt) after 1 and 8 weeks of treatment. DOCA (100 mg/kg) was given by implanting a piece of silicon rubber impregnated with DOCA subcutaneously. Atrial i alpha-rANP increased, while plasma i alpha-rANP decreased with time in all groups. Atrial concentration of i alpha-rANP was significantly lower in the DOCA-salt group than in the other groups at 1 week, and was reduced in the DOCA and DOCA-salt groups as compared to the control group at 8 weeks. On the other hand, plasma concentration of i alpha-rANP was significantly higher in the DOCA and the DOCA-salt groups than in the control group at 1 week; the DOCA and DOCA-salt group values were also higher than the control and salt group values at 8 weeks. Atrial concentration of i alpha-rANP was inversely correlated with systolic blood pressure in the all rats at 1 week (r = 0.48, p less than 0.001) and at 8 weeks (r = 0.33, p less than 0.05). Plasma concentration of i alpha-rANP was positively correlated with systolic blood pressure at 8 weeks (r = 0.37, p less than 0.05). In addition, there was a significant positive correlation between plasma/atrial ratio of i alpha-rANP concentration and systolic blood pressure at either stage (r = 0.41, p less than 0.01 at 1 week; r = 0.40, p less than 0.01 at 8 weeks). Thus, it seems likely that the release of ANPs is increased in response to expansion of extracellular fluid volume or elevation of blood pressure, modifying the development of hypertension in DOCA-salt rats. |
| Databáze: | OpenAIRE |
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