The role of natriuretic peptides in patients with chronic complex (mixed or multiple) heart valve disease
| Autor: | Harvey D. White, Rohan Jayasinghe, Boris Lowe, Ralph A.H. Stewart, Naylin Bissessor, Yong Shen Wee, Andrew Kerr, Luke Kevin Shanahan, Irene Zeng |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cardiac function curve
Male medicine.medical_specialty medicine.drug_class Statistics as Topic Heart Valve Diseases Regurgitation (circulation) Emergency Nursing Sensitivity and Specificity Severity of Illness Index Oxygen Consumption Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Heart valve Prospective Studies Ultrasonography Heart Failure Ejection fraction business.industry Middle Aged medicine.disease Prognosis Peptide Fragments Stenosis medicine.anatomical_structure ROC Curve Heart failure Multivariate Analysis Emergency Medicine Cardiology Exercise Test Linear Models Biomarker (medicine) Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Congestive heart failure (Greenwich, Conn.). 16(2) |
| ISSN: | 1751-7133 |
| Popis: | N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is an important biomarker of prognosis in heart failure and single valve disease. There are limited studies of complex valve disease. Patients with complex valve disease adopt a sedentary lifestyle, so symptoms may be difficult to detect. The authors aimed to determine whether NT-proBNP correlates with the severity of the valve lesion and underlying cardiac function and whether resting NT-proBNP predicts impaired peak VO2 in patients with complex valve disease. Forty-five patients with complex moderate to severe stenosis or regurgitation of the heart valves underwent a clinical assessment, echocardiography, resting NT-proBNP assessment, and formal cardiopulmonary exercise testing. In a multivariate analysis, the log NT-proBNP (β=−9.3, SE=1.9, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text