Structured RNAs that evade or confound exonucleases: function follows form
| Autor: | Benjamin M. Akiyama, Jeffrey S. Kieft, Daniel Eiler |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Exonucleases
0301 basic medicine RNA Stability RNA-binding protein Computational biology Biology Article Structure-Activity Relationship 03 medical and health sciences RNA Transfer Structural Biology Gene expression Animals Humans Small nucleolar RNA Nucleic acid structure Molecular Biology RNA Virology Long non-coding RNA RNA silencing 030104 developmental biology Nucleic Acid Conformation RNA Viral |
| Zdroj: | Current Opinion in Structural Biology. 36:40-47 |
| ISSN: | 0959-440X |
| DOI: | 10.1016/j.sbi.2015.12.006 |
| Popis: | Cells contain powerful RNA decay machinery to eliminate unneeded RNA from the cell, and this process is an important and regulated part of controlling gene expression. However, certain structured RNAs have been found that can robustly resist degradation and extend the lifetime of an RNA. In this review, we present three RNA structures that use a specific three-dimensional fold to provide protection from RNA degradation, and discuss how the recently-solved structures of these RNAs explain their function. Specifically, we describe the Xrn1-resistant RNAs from arthropod-borne flaviviruses, exosome-resistant long non-coding RNAs associated with lung cancer metastasis and found in Kaposi's sarcoma-associated herpesvirus, and tRNA-like sequences occurring in certain plant viruses. These three structures reveal three different mechanisms to protect RNAs from decay and suggest RNA structure-based nuclease resistance may be a widespread mechanism of regulation. |
| Databáze: | OpenAIRE |
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