Differential modulation of zoledronate and etidronate in osseous healing of an extracted socket and tibia defect
| Autor: | Shin Saeng Lim, Beomseok Lee, Soon Jung Hwang, In Sook Kim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Bone Regeneration
Bone density Dentistry Bone healing Zoledronic Acid Pathology and Forensic Medicine Bone remodeling Rats Sprague-Dawley Random Allocation 03 medical and health sciences 0302 clinical medicine Bone Density medicine Animals Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Tooth Socket Bone regeneration Wound Healing Bisphosphonate-associated osteonecrosis of the jaw Bone Density Conservation Agents Diphosphonates Tibia business.industry Imidazoles Etidronic Acid X-Ray Microtomography 030206 dentistry medicine.disease Rats Zoledronic acid 030220 oncology & carcinogenesis Tooth Extraction Bisphosphonate-Associated Osteonecrosis of the Jaw Female Surgery Oral Surgery business Osteonecrosis of the jaw medicine.drug |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 123:8-19 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2016.08.009 |
| Popis: | Objectives Osteonecrosis of the jaw has been increasing after dentoalveolar surgery in patients treated with an antiresorptive bisphosphonate (BP), especially strong zoledronate (ZA). The pathophysiology underlying why osteonecrosis occurs exclusively in the jaw bone remains unclear. This study investigated skeletal site-specific bone healing during the use of BPs to explore the preferential incidence of osteonecrosis of the jaw bone. Study Design Extraction of mandibular molar and creation of a tibia defect were performed in rats 2 weeks after weekly intravenous injections with the potent ZA and the weaker BP etidronate. Bone healing was evaluated radiographically and histologically 1 and 4 weeks after defect creation. Results Bone healing at the extracted socket showed that resorption precedes bone formation, while it was the opposite at the tibia defect. ZA use potentially suppressed bone remodeling, which led to impaired healing at the extracted socket but full regeneration of the tibia defect. However, etidronate showed less suppression of bone remodeling and resulted in increased bone formation at the extracted socket and full regeneration of the tibia defect. Conclusions These results suggest that skeletal site-dependent differences in the bone healing process underlie BP-related preferential occurrence of osteonecrosis of the jaw bone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect