Developing a novel functional disc emulator to investigate the nucleus pulposus replacement
| Autor: | Skip Rochefort, Hassan Mansour Raheem, Brian K. Bay |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Digital image correlation
Nucleus Pulposus Materials science Joint Prosthesis Biomedical Engineering Biophysics Biocompatible Materials Bioengineering 02 engineering and technology Biomaterials Stress (mechanics) Thermoplastic polyurethane Lumbar 0203 mechanical engineering Materials Testing medicine Humans Intervertebral Disc Annulus (oil well) Intervertebral disc 021001 nanoscience & nanotechnology Biomechanical Phenomena 020303 mechanical engineering & transports medicine.anatomical_structure Stress Mechanical 0210 nano-technology Material properties Cadaveric spasm Engineering and Nano-engineering Approaches for Medical Devices Biomedical engineering |
| Zdroj: | Journal of Materials Science. Materials in Medicine |
| ISSN: | 1573-4838 0957-4530 |
| Popis: | We have developed a simple, inexpensive and innovative device for reproducing the global mechanical behavior of spinal motion segments and the local mechanical environment experienced by lumbar intervertebral discs. The device has several broad functions: (1) exploration of the basic mechanics underlying this complex skeletal system, (2) connecting changes in tissue characteristics with overall motion segment function, and (3) evaluation of strategies for repair and replacement of disc components. This “disc emulator” consists of three main parts: (1) an artificial annulus fibrosus (AAF), made out of silicone, with lumbar disc geometry and adjustable material properties, (2) a hydrogel nucleus pulposus (NP) also with lumbar disc geometry and adjustable material properties, and (3) simulated vertebral bodies 3D printed with trabecular bone simulated by a rigid polymer (Acrylonitrile Butadiene Styrene, ABS) and end plates crafted from a compliant polymer (Thermoplastic Polyurethane, TPU). Mechanical compression experiments have been conducted using the disc emulator under similar protocols to published studies of human cadaver samples. Bulging of the artificial annulus fibrosus was examined under axial compression loads using digital image correlation (DIC), and results show close agreement. We see this approach of using anatomical geometry and multiple adjustable components as a useful means of creating accurate local stress/strain environments for preliminary material evaluation, without the variability and difficulty inherent indirect testing of cadaveric materials. |
| Databáze: | OpenAIRE |
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