Synthesis and Evaluation of 5-imino-4-thioxoimidazolidin-2-one Derivatives as Antibacterial and Antifungal Agents
| Autor: | Ahmed M. Sh. El-Sharief, Eman W. El-Gammal, Samir Y. Abbas, Reem A. K. Al-Harbi, Marwa A.M.Sh. El-Sharief |
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| Rok vydání: | 2019 |
| Předmět: |
Antifungal Agents
Chemistry Techniques Synthetic Microbial Sensitivity Tests Alkylation Imidazolidines 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Structure-Activity Relationship Imidazolidine Drug Discovery Candida albicans Organic chemistry Imidazole 030304 developmental biology 0303 health sciences Aryl Antimicrobial Corpus albicans 0104 chemical sciences Anti-Bacterial Agents 010404 medicinal & biomolecular chemistry Klebsiella pneumoniae chemistry Antibacterial activity Bacillus subtilis |
| Zdroj: | Medicinal chemistry (Shariqah (United Arab Emirates)). 17(6) |
| ISSN: | 1875-6638 |
| Popis: | Objective: It was interesting to synthesize some new 5-imino-4-thioxoimidazolidin-2- one derivatives with different halogenated and alkylated aromatic substituents at N-(1) and N-(3) and evaluation of their expected antibacterial and antifungal activities. Methods: New 5-imino-4-thioxoimidazolidin-2-one derivatives were synthesized through the reaction of different halogenated and alkylated N-arylcyanothioformamides with halogenated and alkylated aryl isocyanates. Results: 5-Imino-4-thioxoimidazolidin-2-ones were obtained in high yields with excellent purity. The activities of imidazolidines as antibacterial and antifungal agents were studied. Some of imidazolidine derivatives displayed significant antibacterial and antifungal activities. Conclusion: 5-Imino-4-thioxoimidazolidin-2-ones were obtained in 77-90% yields with excellent purity. The antibacterial and antifungal activities suggest that some of the imidazole derivatives possess significant antimicrobial activity against B. subtilis, K. pneumonia and C. albicans and moderate activity against S. aureus. |
| Databáze: | OpenAIRE |
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