Understanding the Photochemical Properties of Polythiophene Polyelectrolyte Soft Aggregates with Sodium Dodecyl Sulfate for Antimicrobial Activity
| Autor: | Benjamin W. Stein, Mohammed I Khalil, Maksim Y. Livshits, Eva Y. Chi, Dylan M. Brown, Samuel M. Greer, Andrea Scheberl, Erik Reimhult, Edward W. Strach, David G. Whitten, Fahimeh Maghsoodi, Jeffrey J. Rack, Jianzhong Yang |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Polymers Surface Properties Microbial Sensitivity Tests Thiophenes medicine.disease_cause Photochemistry chemistry.chemical_compound Escherichia coli medicine General Materials Science Reactivity (chemistry) Particle Size Sodium dodecyl sulfate chemistry.chemical_classification Molecular Structure Cationic polymerization Sodium Dodecyl Sulfate Polymer Photochemical Processes Polyelectrolytes Polyelectrolyte Anti-Bacterial Agents chemistry Critical micelle concentration Polythiophene Reactive Oxygen Species |
| Zdroj: | ACS Applied Materials & Interfaces. 13:55953-55965 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.1c18553 |
| Popis: | The threat of antibiotic-resistant bacteria is an ever-increasing problem in public health. In this report, we examine the photochemical properties with a proof-of-principle biocidal assay for a novel series of regio-regular imidazolium derivative poly-(3-hexylthiophene)/sodium dodecyl sulfate (P3HT-Im/SDS) materials from ultrafast sub-ps dynamics to μs generation of reactive oxygen species (ROS) and 30 min biocidal reactivity with Escherichia coli (E. coli). This broad series encompassing pure P3HT-Im to cationic, neutral, and anionic P3HT-Im/SDS materials are all interrogated by a variety of techniques to characterize the physical material structure, electronic structure, and antimicrobial activity. Our results show that SDS complexation with P3HT-Im results in aggregate materials with reduced ROS generation and light-induced anti-microbial activity. However, our characterization reveals that the presence of non-aggregated or lightly SDS-covered polymer segments is still capable of ROS generation. Full encapsulation of the P3HT-Im polymer completely deactivates the light killing pathway. High SDS concentrations, near and above critical micelle concentration, further deactivate all anti-microbial activity (light and dark) even though the P3HT-Im regains its electronic properties to generate ROS. |
| Databáze: | OpenAIRE |
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