Diagnostic and Prognostic Accuracy of the Cogstate Brief Battery and Auditory Verbal Learning Test in Preclinical Alzheimer's Disease and Incident Mild Cognitive Impairment: Implications for Defining Subtle Objective Cognitive Impairment
| Autor: | Walter K. Kremers, Shehroo B Pudumjee, Nikki H. Stricker, Ronald C. Petersen, Clifford R. Jack, Emily S. Lundt, Sabrina M. Albertson, Michelle M. Mielke, Mary M. Machulda, David S. Knopman |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Disease Audiology Neuropsychological Tests Verbal learning Article 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Medicine Dementia Humans Cognitive Dysfunction Prospective Studies Aged Aged 80 and over business.industry Working memory General Neuroscience Neuropsychology Cognition General Medicine Middle Aged Verbal Learning medicine.disease Prognosis Psychiatry and Mental health Clinical Psychology 030104 developmental biology Cross-Sectional Studies Positron-Emission Tomography Cohort Auditory Perception Disease Progression Biomarker (medicine) Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | J Alzheimers Dis |
| ISSN: | 1875-8908 |
| Popis: | Background There are detectable cognitive differences in cognitively unimpaired (CU) individuals with preclinical Alzheimer's disease (AD). Objective To determine whether cross-sectional performance on the Cogstate Brief Battery (CBB) and Auditory Verbal Learning Test (AVLT) could identify 1) CU participants with preclinical AD defined by neuroimaging biomarkers of amyloid and tau, and 2) incident mild cognitive impairment (MCI)/dementia. Method CU participants age 50+ were eligible if they had 1) amyloid (A) and tau (T) imaging within two years of their baseline CBB or 2) at least one follow-up visit. AUROC analyses assessed the ability of measures to differentiate groups. We explored the frequency of cross-sectional subtle objective cognitive impairment (sOBJ) defined as performance ≤-1 SD on CBB Learning/Working Memory Composite (Lrn/WM) or AVLT delayed recall using age-corrected normative data. Results A+T+ (n = 33, mean age 79.5) and A+T- (n = 61, mean age 77.8) participants were older than A-T- participants (n = 146, mean age 66.3), and comparable on sex and education. Lrn/WM did not differentiate A + T+or A+T- from A-T- participants. AVLT differentiated both A+T+ and A+T- from A-T- participants; 45% of A+T+ and 25% of A+T- participants met sOBJ criteria. The follow-up cohort included 150 CU individuals who converted to MCI/dementia and 450 age, sex, and education matched controls. Lrn/WM and AVLT differentiated between stable and converter CU participants. Conclusion Among CU participants, AVLT helped differentiate A+T+ and A+T- from A-T- participants. The CBB did not differentiate biomarker subgroups, but showed potential for predicting incident MCI/dementia. Results inform future definitions of sOBJ. |
| Databáze: | OpenAIRE |
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